Preliminary reports show conolidine could inhibit unique ion channels, lowering neuronal excitability and restricting discomfort indicators. This mechanism is especially suitable in neuropathic agony, in which irregular signaling brings about persistent discomfort. In addition, conolidine seems to influence G protein-coupled receptor (GPCR) pathway
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Although the opiate receptor depends on G protein coupling for signal transduction, this receptor was found to employ arrestin activation for internalization with the receptor. Usually, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable improvement in binding efficacy. This binding in the lo
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